89s52  is widely used  IC in 8051 FAMILY.

It is programmed using ICSP with an external programmer USBASP (AVRDUDE).89S52 has no BOOTLOADER , so it cannot be programmed through SERIAL Port.

W78E052DDG is 8051 compatible 8-bit controller from Nuvoton with 8K programmable flash memory in 40 Pin DIP package,This chip has separate dedicated 2K boot-loader memory, which makes this chip robust and very stable .It supports ISP program downloading from PC using RX-TX lines only.

Other specifications match exactly 89S52.

It contains an 8K-byte Flash EPROM , a 256-byte RAM; four 8-bit bi-directional (P0, P1, P2, P3) and bit-addressable I/O ports , an additional 4-bit I/O port P4; three 16-bit timer/counters ,  a hardware watchdog timer , and a serial port  , The instruction set is fully compatible with the standard 8052. Note that the actual part number of the chip in the 40-pin DIP package is W78E052DDG